Inhibition by TGF-beta 1 of the in vitro thymulin-stimulated proliferation of gonocytes from fetal rat testes.
نویسندگان
چکیده
The cytokine transforming growth factor beta 1 (TGF-beta 1) inhibits the growth of certain cells and the differentiation of others. A thymus hormone, thymulin, stimulated the proliferation of fetal male germ cells in explants of testes from 13.5 gestation day rat fetuses. The way in which thymulin acts is unknown. Adding TGF-beta 1 to the culture medium blocked the response of the fetal male rat germ cells to thymulin. We suggest that TGF-beta 1 and thymulin may thus influence the same metabolic chain of events.
منابع مشابه
Effects of thymulin on in vitro incorporation of 3H-thymidine into gonocytes of newborn rat testes.
3H-Thymidine incorporation into gonocytes was investigated by means of quantitative autoradiography in organ cultures of testes from newborn rats between day 0 (day of birth) and day 7, in the presence or absence of thymulin. The data indicated that thymulin had no effect on gonocyte incorporation on day 0 or on days 1 and 7; in contrast, thymulin had a strong effect on day 2. At day 2 the perc...
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عنوان ژورنال:
- Reproduction, nutrition, development
دوره 37 2 شماره
صفحات -
تاریخ انتشار 1997